Job Description

Job Description

Principal Investigator - Clinical Research (Cardiology)
Location: Multiple (Denver, CO)
Employment Type: Full-Time / Part-Time / Contract
Compensation: $150 - $250 per hour (commensurate with speciality, experience, and contract type)
Schedule: Flexible | Part-Time (0-8 hours/week) or Full-Time options

We are seeking an experienced and board-certified Cardiologist (or physician in a related specialty) to serve as Principal Investigator (PI) for ongoing and upcoming clinical research trials. The PI will provide medical leadership, ensure scientific integrity, and maintain regulatory and ethical compliance throughout all phases of the research process.

This role is ideal for physicians passionate about advancing cardiovascular and multi-specialty research, with flexibility to balance clinical and research commitments.

• Medical Leadership & Oversight

  • Serve as the Principal Investigator for assigned clinical trials, providing overall medical direction and scientific guidance.

  • Oversee all aspects of study conduct, ensuring compliance with the protocol, ICH-GCP, FDA, and institutional standards.

  • Ensure participant eligibility, informed consent, and ongoing safety monitoring.

• Patient Evaluation & Safety

  • Perform or review medical screenings, physical examinations, and specialty-specific assessments.

  • Assess and document adverse events (AEs/SAEs), determine relatedness, and ensure timely reporting to regulatory bodies and sponsors.

  • Maintain ongoing medical oversight of participants throughout the study duration.

• Protocol Compliance & Data Integrity

  • Ensure accurate and complete documentation of study data in source records and EDC systems.

  • Review and sign off on all critical study documents, including CRFs, medical histories, and AE reports.

  • Participate in and support site monitoring visits, audits, and inspections.

• Collaboration & Communication

  • Work closely with Clinical Research Coordinators, regulatory staff, and sponsor representatives to ensure protocol adherence and operational efficiency.

  • Participate in Investigator Meetings, Site Initiation Visits (SIVs), and other sponsor-mandated sessions.

  • Provide medical insights during protocol development, feasibility reviews, and recruitment strategy discussions.

• Quality & Compliance

  • Uphold GCP and FDA regulations; implement corrective and preventive actions (CAPA) as needed.

  • Ensure proper delegation of responsibilities to Sub-Investigators and research staff, with ongoing supervision and documentation.

  • Maintain up-to-date knowledge of current research methodologies, cardiology therapeutics, and regulatory changes.

• MD or DO degree with an active, unrestricted U.S. medical license (CO and/or IL strongly preferred).

• Board Certification in Cardiology (Interventional, Electrophysiology, or Heart Failure subspecialties welcome).

• Minimum of 2 years' experience as a Principal Investigator or Sub-Investigator in clinical research.

• Current BLS and ACLS certifications; DEA license preferred.

• Proficiency with EHR, EDC, and CTMS systems.

• Strong leadership, documentation, and communication skills.

• Commitment to patient safety, protocol fidelity, and ethical research practices.

• $150 - $250/hour depending on speciality, experience, and contract scope.

• Flexible engagement options (part-time or full-time).

• Access to multi-therapeutic and cardiovascular trials at cutting-edge research facilities.

• Professional growth as a senior investigator and potential for long-term research leadership roles.

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